Fibroblast Growth Factor 23 Is Associated With Subclinical Cerebrovascular Damage
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Fibroblast Growth Factor 23 Is Associated With Subclinical Cerebrovascular Damage
Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate homeostasis and when elevated increases cardiovascular disease and stroke risk and mortality. However, most studies of FGF23 have focused on those with chronic kidney disease (CKD). Less data are available from the general population, especially with respect to stroke. We previously reported elevated FGF23 in...
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BACKGROUND AND PURPOSE Elevated fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and is linked with mortality, cardiovascular events, and stroke. However, the role of FGF23 as a risk factor for subclinical cerebrovascular damage is unclear. METHODS We used multivariable linear and logistic regression to evaluate associations between FGF23, continuously and by quartiles, wit...
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Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in patients with chronic kidney disease. As a potential mediating mechanism, FGF23 induces left ventricular hypertrophy; however, its role in arterial calcification is less clear. In order to study this, we quantified coronary artery and thoracic aorta calcium by computed tomography in 1501 patients from the ...
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Our purpose was to assess the relationship between serum fibroblast growth factor 23 (FGF23) and left ventricular function, carotid intima-media thickness (CIMT) and laboratory features in children on peritoneal dialysis (PD). The study population consisted of 17 patients (11 female; median age 7.83 years, range 0.66-17.75) undergoing PD for 22 months (range 2-98). Serum FGF23, serum phosphorus...
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Fibroblast growth factor-23 is a bone-derived hormone that increases urinary phosphate excretion and inhibits hydroxylation of 25-hydroxyvitamin D. Recent studies suggest that fibroblast growth factor-23 may be an early biomarker of CKD progression. However, its role in kidney function decline in the general population is unknown. We assessed the relationship between baseline (1990-1992) serum ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2016
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.115.012379